Bone turnover markers predict changes in bone mineral density in men treated with abaloparatide: results from the abaloparatide for the treatment of men with osteoporosis (ATOM) study
Authors' conclusion
These data support that early changes in BTMs in men treated with abaloparatide are associated with subsequent changes in BMD similar to what has been reported in women.
Study context
- Population
- Men with osteoporosis in the randomized phase 3 ATOM study; compared with women from the ACTIVE study
- Comparison
- Correlation of early BTM changes with 12-mo BMD increase in abaloparatide-treated men; men vs women (ACTIVE)
- Primary endpoint
- Correlation (Pearson's) between changes from baseline in PINP and CTX at 1, 3, 6 and 12 mo and percent increase from baseline in BMD at 12 mo
- Follow-up
- 12 mo
Methodological detailsphase 3, comparison with women from the ACTIVE study
- Phase 3
- Comparison with women from the ACTIVE study
Primary result
As reported in the abstract
Correlation of PINP increases with 12-mo LS BMD increases in abaloparatide-treated men
- PINP at 1 mo, r
- 0.485
- PINP at 3 mo, r
- 0.614
- PINP at 6 mo, r
- 0.632
- PINP at 12 mo, r
- 0.521
- All highly correlated
- p < .0001
Further findings
Mean
| Outcome | Abaloparatide | Placebo |
|---|---|---|
| Mean uncoupling index (UI) · 1 mo | 2.26 | −0.25 |
Mean UI, men vs women · month 3
- Mean UI in men (greater)
- 1.32
- Mean UI in women
- 0.88
- Men vs women
- P < 0.001
Correlation of 3-mo UI with 12-mo LS BMD
- Men, r
- 0.453; p < .001
- Women, r
- 0.252; p < .01
Correlation of 6- and 12-mo UI with 12-mo LS BMD · months 6 and 12
- Significantly correlated in men and women; correlation stronger in men than women
Original publication
Bone turnover markers predict changes in bone mineral density in men treated with abaloparatide: results from the abaloparatide for the treatment of men with osteoporosis (ATOM) study. J Bone Miner Res. Published 10 January 2025. doi:10.
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