Osteoporosis, bone & mineral

Vitamin D Status During Adolescence and the Impact of Lifestyle Changes: 2 Years’ Follow-up From the Fit Futures Study

J Clin Endocrinol MetabPublished Longitudinal population-based cohort study

Authors' conclusion

Severe vitamin D deficiency was prevalent throughout adolescence. Lifestyle changes may alter s-25(OH)D levels in this age group.

Study context

Population
Arctic adolescents at 69°N in Norway, s-25(OH)D measured in first and third year of upper secondary school (median age 16 and 18 years)longitudinal data
Participants
589 adolescents
Exposure
Girls vs Boys
  • Girlsn = 309
  • Boysn = 280
Outcome
Change in vitamin D status (s-25(OH)D) over 2 years in adolescence
Follow-up
FF1 (median age 16) and FF2 (median age 18)
Methodological details2-year follow-up
  • 2-year follow-up

Main finding

As reported in the abstract

Vitamin D status (s-25(OH)D) · FF1 and FF2
s-25(OH)D <50 nmol/L, FF1
73.7%
s-25(OH)D <50 nmol/L, FF2
77.1%
s-25(OH)D <30 nmol/L, FF1
35.7%
s-25(OH)D <30 nmol/L, FF2
40.9%
Severely deficient (<30 nmol/L) in FF1 who remained severely deficient in FF2
73.3%

Observational data: associations, not effects.

Further findings

Severe vitamin D deficiency (s-25(OH)D <30 nmol/L) persistence · FF1 to FF2

Of those with s-25(OH)D <30 nmol/L in FF1, remained severely deficient in FF2
73.3%

Association of lifestyle changes with s-25(OH)D at FF2, boys (regression controlling for baseline s-25(OH)D)

Increase in UV exposure, beta (nmol/L); CI
12.9; 9.1, 16.7
  • Controlling for baseline s-25(OH)D levels

Association of lifestyle changes with s-25(OH)D at FF2, girls (regression controlling for baseline s-25(OH)D)

Decreased vitamin/mineral supplement intake, beta (nmol/L); CI
−6.7; −10.2, −3.1
Increased UV exposure, beta (nmol/L); CI
10.8; 7.0, 14.7
Combined hormonal contraceptive exposure in FF2, beta (nmol/L); CI
12.1; 6.0, 18.1
  • Controlling for baseline s-25(OH)D levels

Original publication

Vitamin D Status During Adolescence and the Impact of Lifestyle Changes: 2 Years’ Follow-up From the Fit Futures Study. J Clin Endocrinol Metab. Published 13 November 2023. doi:10.1210/clinem/dgad655

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