A simple fragility fracture risk score for type 2 diabetes patients: a derivation, validation, comparison, and risk stratification study
Authors' conclusion
These novel scores enable simple and reliable fracture risk stratification in T2D patients. Future work is needed to validate these findings in external cohort(s).
Study context
- Population
- Patients with T2D enrolled January 2015 to August 2019
- Participants
- 1,855 patients
- Comparison
- New simple fracture risk scores vs FRAX and its adjustments
- Outcome
- Any fragility fracture (AF) and major osteoporotic fracture (MOF)
- Follow-up
- Median 5 years
Methodological detailslongitudinal cohort, Cox proportional hazard regression, internal validation by bootstrap resampling (1000)
- Longitudinal cohort
- Cox proportional hazard regression
- Internal validation by bootstrap resampling (1000)
Performance
As reported in the abstract
Fracture risk prediction performance
- Concordance index (C-index) and calibration plots indicated improved identification performance with the new scores
- Improved decision curve analysis (DCA) and AUC with the new scores vs FRAX and its derivatives
- Scores separated T2D patients into risk groups with significant differences in fracture incidence
Further findings
Fracture incidence · median follow-up 5 years
- Any fragility (AF) cases
- 119 (6.42%)
- Major osteoporotic fracture (MOF) cases
- 92 (4.96%)
Original publication
A simple fragility fracture risk score for type 2 diabetes patients: a derivation, validation, comparison, and risk stratification study. Eur J Endocrinol. Published 13 November 2023. doi:10.
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