Lipids & metabolic liver disease
Association between liver fibrosis severity and impaired myocardial glucose metabolism in subjects with different degrees of glucose tolerance
Authors' conclusion
These data suggest that impairment of insulin-stimulated myocardial glucose metabolism is associated with a high risk of advanced liver fibrosis in individuals with varying degrees of glucose tolerance.
Study context
- Population
- Individuals with varying degrees of glucose tolerance
- Participants
- 57 individuals
- Exposure
- High vs intermediate vs low risk of liver fibrosis by FIB-4 index
- Low riskn = 37reference
- Intermediate riskn = 16
- High riskn = 4
- Outcome
- Insulin-stimulated myocardial glucose metabolic rate (MrGlu) by FIB-4 liver fibrosis risk
Methodological detailscardiac dynamic 18F-FDG positron emission tomography (PET), euglycemic-hyperinsulinemic clamp
- Cardiac dynamic 18F-FDG PET
- Euglycemic-hyperinsulinemic clamp
Main finding
As reported in the abstract
High risk
4.6
mean · SD 4.3 · µmol/min/100 g
Low risk
21.7
mean · SD 11.2 · µmol/min/100 g
Intermediate risk
20.
mean · SD 11.03 · µmol/min/100 g
High risk vs Low risk: P = 0.009 · High risk vs Intermediate risk: P = 0.01
Observational data: associations, not effects.
Further findings
Glycemic and anthropometric parameters, whole-body insulin sensitivity, blood pressure
- No significant differences between groups
Multivariable regression: variables associated with advanced liver fibrosis risk
- Myocardial MrGlu was the only significantly associated variable, β
- −0.286
- P
- P = 0.003
- Variation explained
- 28.6%
Original publication
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