Lipids & metabolic liver disease
Association between liver fibrosis and decreased myocardial mechano-energetic efficiency in individuals with different degree of glucose tolerance
Authors' conclusion
Compromised myocardial MEEi is already reported in individuals with high risk of hepatic fibrosis suggesting that its assessment may help to identify among subjects with NAFLD those with worst prognosis.
Study context
- Population
- Individuals with different degree of glucose tolerance in the CATAMERI study
- Participants
- 2,383 individuals
- Exposure
- FIB-4 categories of liver fibrosis risk
- Outcome
- Association between liver fibrosis severity (FIB-4) and echocardiography-derived myocardial MEEi
Main finding
As reported in the abstract
Myocardial MEEi
FIB-4 independently associated with mechano-energetic efficiency (MEEi) (multivariable regression), β
−0.080
P < 0.001
Observational data: associations, not effects.
Further findings
Other independent correlates of MEEi (multivariable regression)
- Total cholesterol, β
- −0.067, P = 0.01
- hsCRP, β
- −0.081, P < 0.001
- Sex, β
- −0.099, P < 0.001
- Glucose tolerance status, β
- −0.109, <0.001
- HOMA-IR, β
- −0.143, P < 0.001
Original publication
Association between liver fibrosis and decreased myocardial mechano-energetic efficiency in individuals with different degree of glucose tolerance. Diabetes Res Clin Pract. Published 22 March 2023. doi:10.
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