Lipids & metabolic liver disease
Genetically predicted visceral adipose tissue and risk of nine non-tumour gastrointestinal diseases: evidence from a Mendelian randomization study
Authors' conclusion
This study provided evidence in support of causal associations between VAT and GORD, GU, DU, cholelithiasis, AP, and NAFLD. Moreover, the associations between GORD, GU, and NAFLD were independent of the effect of BMI.
Study context
- Population
- Nine non-tumour gastrointestinal diseases
- Comparison
- Genetically predicted higher visceral adipose tissue (VAT) vs lower VAT
- Outcome
- Risk of nine non-tumour gastrointestinal diseases
Methodological detailsinverse-variance weighted method, complementary and multivariable Mendelian randomization (MR) analyses
- Inverse-variance weighted method
- Complementary and multivariable MR analyses
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
Higher VATGORD
1.21(1.09–1.34)
P = 3.06 × 10-4Higher VATDU
1.40(1.10–1.77)
P = 0.005Higher VATCholelithiasis
1.75(1.53–2.00)
P = 1.14 × 10-16Higher VATNAFLD
2.68(1.87–3.82)
P = 6.26 × 10-8VATGU; suggestive association
1.22(1.01–1.48)
P = 0.035VATAcute pancreatitis; suggestive association
1.26(1.05–1.52)
P = 0.013Further findings
Multivariable MR adjusted for body mass index (BMI)
- Associations with gastro-oesophageal reflux disease (GORD), gastric ulcer (GU) and non-alcoholic fatty liver disease (NAFLD) remained after adjustment for BMI
Original publication
Genetically predicted visceral adipose tissue and risk of nine non-tumour gastrointestinal diseases: evidence from a Mendelian randomization study. Int J Obes (Lond). Published 18 March 2023. doi:10.
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