Association between atherogenic index of plasma control level and incident cardiovascular disease in middle-aged and elderly Chinese individuals with abnormal glucose metabolism
Authors' conclusion
In middle-aged and elderly participants with abnormal glucose metabolism, constant higher AIP with worst control may have a higher incidence of CVD. Monitoring long-term AIP change will contribute to early identification of high risk of CVD among individuals with abnormal glucose metabolism.
Study context
- Population
- Middle-aged and elderly Chinese participants with abnormal glucose metabolism (diabetes and pre-diabetes), China Health and Retirement Longitudinal Study
- Participants
- 2,659 participants
- Exposure
- Atherogenic index of plasma (AIP) control level classes 2–5 vs class 1
- Outcome
- Incident CVD (self-reported heart disease and/or stroke)
- Follow-up
- Within 3 years
Methodological detailsk-means clustering of AIP control level, multivariable logistic regression, restricted cubic spline analysis
- K-means clustering of AIP control level
- Multivariable logistic regression
- Restricted cubic spline analysis
Main finding
As reported in the abstract
Incident CVD
Each group vs class 1Odds ratio (95% CI)
Class 2
1.31(0.90–1.90)
Class 3
1.38(0.99–1.93)
Class 4
1.46(1.01–2.10)
Class 5
1.56(1.03–2.37)
- Participants progressing to cardiovascular disease (CVD)
- 398 (14.97%)
Observational data: associations, not effects.
Further findings
Dose–response (restricted cubic spline)
- Relationship between cumulative AIP index and CVD is linear
Subgroup analysis
- Similar results in agricultural Hukou, history of smoking, diastolic BP ≥ 80mmHg and normal BMI subgroups
- No interaction between AIP control level and subgroup variables
Original publication
Association between atherogenic index of plasma control level and incident cardiovascular disease in middle-aged and elderly Chinese individuals with abnormal glucose metabolism. Cardiovasc Diabetol. Published 8 February 2024. doi:10.
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