The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old
Authors' conclusion
A constant higher level with worst control in TyG index indicated a higher risk of stroke.
Study context
- Population
- General population; stroke incidence over 3 years
- Participants
- 4,710 participants
- Exposure
- Triglyceride-glucose (TyG) index change classes 2–5 vs class 1
- Outcome
- Incidence of stroke
- Follow-up
- 3 years
Methodological detailsk-means clustering of TyG index change, logistic regression, restricted cubic spline regression
- K-means clustering of TyG index change
- Logistic regression
- Restricted cubic spline regression
Main finding
As reported in the abstract
Stroke
Each group vs class 1Odds ratio (95% CI)
Class 2
1.427(1.051–1.938)
Class 3
1.714(1.245–2.359)
Class 4
1.814(1.257–2.617)
Class 5
2.161(1.446–3.228)
Class 3after multivariable adjustment; only class 3 remained associated
1.430(1.022–2.000)
- Stroke during 3 years
- 369 (7.8%) of 4710
Observational data: associations, not effects.
Further findings
Cumulative TyG index and stroke
- Linear relation in restricted cubic spline regression
Subgroups without diabetes or dyslipidemia
- Similar results in participants without diabetes or dyslipidemia
- Neither additive nor multiplicative interaction between TyG index class and covariates
Original publication
The change of triglyceride-glucose index may predict incidence of stroke in the general population over 45 years old. Cardiovasc Diabetol. Published 9 June 2023. doi:10.
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