The relationship between longitudinal changes in triglyceride-glucose-body mass index and new-onset diabetes in middle-aged and elderly adults: Evidence from a nationwide Chinese cohort study
Authors' conclusion
TyG-BMI changes and sustained exposure to high TyG-BMI levels are independently linked to increased DM risk. Monitoring long-term fluctuations in TyG-BMI could be an important strategy for preventing DM, and effectively controlling high TyG-BMI through various interventions may significantly reduce DM risk.
Study context
- Population
- Middle-aged and elderly adults in China (CHARLS); TyG-BMI changes 2011–2015
- Exposure
- TyG-BMI change classes vs consistently low TyG-BMI
- Outcome
- New-onset DM
Methodological detailsnationwide, K-means clustering of TyG-BMI changes, Cox proportional hazards regression
- Nationwide
- K-means clustering of TyG-BMI changes
- Cox proportional hazards regression
Main finding
As reported in the abstract
DM
Hazard ratio
1.474
Class 2
Hazard ratio
2.250
Class 3
Hazard ratio
3.142
Class 4
Observational data: associations, not effects.
Further findings
Diabetes mellitus (DM) per 10-unit △TyG-BMI2015-2011
- HR, class 2
- 1.064
- HR, class 3
- 1.108
- HR, class 4
- 1.079
DM per 10-unit cumulative TyG-BMI
- HR
- 1.029
Original publication
The relationship between longitudinal changes in triglyceride-glucose-body mass index and new-onset diabetes in middle-aged and elderly adults: Evidence from a nationwide Chinese cohort study. Diabetes Res Clin Pract. Published 27 March 2025. doi:10.
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