Association between C-reactive protein-triglyceride glucose index and stroke risk in different glycemic status: insights from the China Health and Retirement Longitudinal Study (CHARLS)
Authors' conclusion
Our findings revealed a significant positive linear relationship between CTI and the occurrence of stroke. The association between CTI and stroke was similar between male and female, and similar in middle-aged and elderly participants. In different glycemic status, the association was significant in individuals with NGR and Pre-DM.
Study context
- Population
- Middle-aged and elderly participants, China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 10,443 participants
- Exposure
- CTI and stroke risk by glycemic status
- Outcome
- Occurrence of stroke events
- Follow-up
- Median 9 years
Methodological detailspopulation-based (CHARLS), CTI = 0.412* Ln (CRP [mg/L]) + Ln (TG [mg/dl] × FPG [mg/dl])/2, Kaplan-Meier curves, Cox proportional hazard models and restricted cubic spline analysis
- Population-based (CHARLS)
- CTI = 0.412* Ln (CRP [mg/L]) + Ln (TG [mg/dl] × FPG [mg/dl])/2
- Kaplan-Meier curves, Cox proportional hazard models and restricted cubic spline analysis
Main finding
As reported in the abstract
Stroke risk with high CTI, by glycemic status
Hazard ratio (95% CI)
NGR
1.33(1.11–1.59)
Pre-DM
1.20(1.04–1.39)
- Participants with stroke
- 960 (9.2%)
Observational data: associations, not effects.
Further findings
Stroke risk with CTI, by sex
| HR (95% CI) | ||
|---|---|---|
| Females | 1.22 (1.09–1.36) | |
| Males | 1.15 (1.02–1.29) | |
| 0.512Hazard ratio (log scale) |
Stroke risk with CTI, by age
| HR (95% CI) | ||
|---|---|---|
| Middle-aged | 1.25 (1.11–1.41) | |
| Elderly | 1.12 (1.00–1.26) | |
| 0.512Hazard ratio (log scale) |
Stroke risk with CTI, by sex
- Association similar between male and female, HR tended to be higher in females
Stroke risk with CTI, by age
- Association similar in middle-aged and elderly participants
Original publication
Association between C-reactive protein-triglyceride glucose index and stroke risk in different glycemic status: insights from the China Health and Retirement Longitudinal Study (CHARLS). Cardiovasc Diabetol. Published 26 March 2025. doi:10.
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