Cardiovascular abnormalities already occurred in newly-diagnosed patients with early-onset type 2 diabetes
Authors' conclusion
Heart and carotid artery abnormalities are common in patients with early-onset T2DM at the time of diagnosis. Patients with obesity and insulin resistance are at higher risk for cardiovascular abnormalities. Cluster classification based on clinical characteristics enables more accurate identification of patients at increased risk of cardiovascular complications at an early stage.
Study context
- Population
- Patients ≤40 years old with newly diagnosed T2D, START cohort; echocardiography and carotid US within 3 months of diagnosis
- Participants
- 400 patients
- Exposure
- Cardiovascular abnormalities across diabetes cluster phenotypes
- Outcome
- Prevalence of cardiovascular abnormalities
- Follow-up
- Within 3 months of diagnosis
Methodological detailscross-sectional screening at diagnosis, K-means cluster classification, partitioned polygenic scores
- Cross-sectional screening at diagnosis
- K-means cluster classification
- Partitioned polygenic scores
Main finding
As reported in the abstract
Carotid artery abnormalities
26.3%
Echocardiography abnormalities
20.0%
Observational data: associations, not effects.
Further findings
Left atrial enlargement by cluster
| Outcome | SIRD | MOD |
|---|---|---|
| Carotid artery abnormality by cluster | 40.0% | — not stated in the abstract |
| Abnormal left ventricular geometry | 36.1% | — not stated in the abstract |
— not stated in the abstract
- Carotid artery abnormality by cluster — Fasting C-peptide associated with increased risk of carotid artery abnormalities (adjusted)
- 1.247-fold
- Left atrial enlargement by cluster — Increase in left atrial enlargement risk with increasing BMI, fasting C-peptide and HOMA2IR, respectively
- 1.136-, 1.781- and 1.687-fold
Carotid artery abnormality by cluster
- Severe insulin resistant diabetes (SIRD) had the highest incidence
Partitioned polygenic scores (pPS) for lipodystrophy
- Linear correlation with LAAP/BSA
- R = 0.344, p < 0.001
- Higher in EOD with plaque formation
Original publication
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