Association between body roundness index and new-onset stroke risk in middle-aged and older adults with varying glucose metabolism status: A longitudinal study using CHARLS data
Authors' conclusion
This study identified elevated BRI independently predicts stroke risk, particularly in individuals with impaired glucose regulation.
Study context
- Population
- Middle-aged and older adults with varying glucose metabolism status (normal glucose regulation (NGR), Pre-DM, diabetes mellitus (DM)), China Health and Retirement Longitudinal Study (2011–2020)
- Participants
- 7,969 participants
- Exposure
- Higher vs lower baseline body roundness index (BRI)
- Outcome
- New-onset stroke
Methodological detailslongitudinal, propensity score matching, restricted cubic splines, sensitivity analyses
- Longitudinal
- Propensity score matching
- Restricted cubic splines
- Sensitivity analyses
Main finding
As reported in the abstract
Stroke risk by baseline BRI
BRI and stroke risk, adjusted HR
1.78
95% CI 1.30–2.43P for trend < 0.001
Observational data: associations, not effects.
Further findings
Stroke prediction (ROC)
- BRI AUC, superior to other measures
- 0.678
- BRI AUC in Pre-DM
- 0.716
- BRI AUC in DM
- 0.671
- BRI combined with biomarkers may improve stroke prediction accuracy
Original publication
Association between body roundness index and new-onset stroke risk in middle-aged and older adults with varying glucose metabolism status: A longitudinal study using CHARLS data. Diabetes Res Clin Pract. Published 9 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →