Changes in abdominal subcutaneous adipose tissue thickness associate with disease and anthropometric factors
Authors' conclusion
3D quantification and morphometric analysis of ASAT offer novel insights into the associations between abdominal fat distribution, lifestyle factors, and chronic disease risk. These techniques hold promise for enhancing our understanding of fat-related disease mechanisms in population-level studies.
Study context
- Population
- UK Biobank participants with baseline abdominal MRI; subset with follow-up scan ≈2 years later3,088 with follow-up scan
- Participants
- 44,515 participants
- Outcome
- Associations of ASAT thickness
Methodological detailsUK Biobank, MRI, 3D surface meshes, statistical parametric maps, statistical shape analysis, longitudinal follow-up subset
- UK Biobank
- MRI
- 3D surface meshes
- Statistical parametric maps
- Statistical shape analysis
- Longitudinal follow-up subset
Main finding
As reported in the abstract
Hip abdominal subcutaneous adipose tissue (ASAT) thickness regional variation and incident cardiovascular disease (CVD) in women, HR
0.90
95% CI 0.84–0.97p = 0.023
Hip ASAT thickness regional variation and hypertension in women, HR
1.10
95% CI 1.03–1.21p = 0.045
Hip ASAT thickness regional variation and hypertension in men, HR
0.88
95% CI 0.82–0.96p = 0.014
Observational data: associations, not effects.
Further findings
Longitudinal change in ASAT thickness · 2.5-year period
- Significant changes in ASAT thickness in both sexes, independent of disease status at baseline
Original publication
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