Risk Factors for Hyperosmolar Hyperglycemic State in Pediatric Type 2 Diabetes
Authors' conclusion
While DKA represents the most admissions for hyperglycemic emergencies among pediatric T2D, those admitted for HHS had higher severity of illness and mortality. Male gender and Black race were associated with HHS admission compared to DKA. Additional studies are needed to understand the drivers of these risk factors.
Study context
- Population
- Pediatric admissions for diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS) among youth with T2D (aged ≥9 years), Kids' Inpatient Database 2006, 2009, 2012 and 2019
- Participants
- 8,961 admissions
- Exposure
- HHS vs DKA admissions
- Outcome
- Factors associated with admission for HHS compared with DKA
Methodological detailsnational Kids' Inpatient Database, ICD-code identified admissions
- National Kids' Inpatient Database
- ICD-code identified admissions
Main finding
As reported in the abstract
Factors associated with HHS vs DKA admission (adjusted)
- Male sex: adjusted OR for HHS vs DKA
- OR 1.77, 95% CI 1.42-2.21
- Black vs White race: adjusted OR for HHS vs DKA
- OR 1.81, 95% CI 1.34-2.44
Observational data: associations, not effects.
Further findings
| Outcome | Odds |
|---|---|
| Major or extreme severity of illness | 11.3-fold higher |
| Mortality | 5.0-fold higher |
Original publication
Risk Factors for Hyperosmolar Hyperglycemic State in Pediatric Type 2 Diabetes. Pediatr Diabetes. Published 9 June 2023. doi:10.
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