Diabetes, fasting blood glucose and the efficacy of remote ischaemic conditioning: A secondary analysis of the Remote Ischaemic Conditioning for Acute Moderate Ischaemic Stroke (RICAMIS) trial
Authors' conclusion
Diabetes and FBG levels did not influence the neuroprotective effect of RIC in acute moderate ischaemic stroke, although diabetes and high FBG levels were independently associated with functional outcomes.
Study context
- Population
- Patients with acute moderate ischaemic stroke in the RICAMIS trial; 535 with diabetes and 1172 without diabetespost hoc
- Participants
- 1,707 patients
- Comparison
- Remote ischaemic conditioning (RIC) vs control, by diabetes status and fasting blood glucose (FBG) level
- Primary endpoint
- Excellent functional outcome: Modified Rankin Scale (mRS) score 0 to 1
- Follow-up
- 90 days
Methodological detailspost hoc
- Post hoc
Primary result
As reported in the abstract
Excellent functional outcome (mRS 0–1), by diabetes status and FBG
RIC vs ControlOdds ratio (95% CI)P value
Non-diabetic: 70.5% vs. 63.2%
1.487(1.134–1.949)
P = 0.004Diabetic: 65.3% vs. 59.8%
1.424(0.978–2.073)
P = 0.065Normal FBG: 69.3% vs. 63.7%
1.363(1.011–1.836)
P = 0.042High FBG: 64.2% vs. 58%
1.550(1.070–2.246)
P = 0.02- No interaction of intervention (RIC or control) with diabetes status or FBG levels on clinical outcomes
- P > 0.05 for all
Further findings
Association with functional outcomes in patients overall
- Diabetes: OR 0.741, 95% CI 0.585-0.938
- P = 0.013
- High FBG: OR 0.715, 95% CI 0.553-0.925
- P = 0.011
- Independently associated
Original publication
Diabetes, fasting blood glucose and the efficacy of remote ischaemic conditioning: A secondary analysis of the RICAMIS trial. Diabetes Obes Metab. Published 8 June 2023. doi:10.
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