Efficacy and Safety of Analog Insulin in Comparison With Human Insulin for Hyperglycemia in Hospitalized Patients With Acute Stroke: A Randomized, Open-Label, Single-Center Trial
Authors' conclusion
Hospitalized patients acute stroke and hyperglycemia exhibited similar mean BG but a trend of lower incidence of severe hypoglycemia when treated with analog insulins in comparison with human insulin.
Study context
- Population
- Hospitalised patients with acute stroke (52 ischemic, 50 hemorrhagic) and hyperglycemia; age 59.4 ± 11.7 years, 54 women; February–June 2021
- Participants
- 102 patients
- Comparison
- Analog insulin vs human insulin
- Analog insulinn = 52
- Human insulinn = 50reference
- Primary endpoint
- Mean daily BG and number of hypoglycemic events
Methodological detailssingle-centre, open-label, Insulin initiated and titrated per predefined standard protocol; capillary blood glucose (BG) monitored by standardized glucometers
- Single-centre
- Open-label
- Insulin initiated and titrated per predefined standard protocol; capillary BG monitored by standardized glucometers
Primary result
As reported in the abstract
- Analog insulin vs Human insulin: P > 0.05 for all days
- Analog insulin vs Human insulin: P = 0.727
Further findings
| Outcome | P value |
|---|---|
| Daily total insulin requirementTendency toward lower with analog insulin | P = 0.053 |
| Bolus insulin doseSignificantly lower with analog insulin | P = 0.029 |
| Basal insulin doseSimilar | P = 0.167 |
| Hospital mortality, modified Rankin Scale score on outcome, LOSNo significant difference | P = 0.729 |
Safety
| Outcome | Human insulin | P value |
|---|---|---|
| Severe hypoglycemiaAll 4 severe events with human insulin | 4 events | P = 0.054 |
- Hypoglycemic episodes (frequency) · no significant difference
- P = 0.727
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Efficacy and Safety of Analog Insulin in Comparison With Human Insulin for Hyperglycemia in Hospitalized Patients With Acute Stroke: A Randomized, Open-Label, Single-Center Trial. Endocr Pract. Published 1 November 2022. doi:10.
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