Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes
Authors' conclusion
Our study suggests that increased beta cell workload is accompanied by a progressive increase in ER stress with defects in insulin synthesis and loss of beta cell identity.
Study context
- Population
- Metabolically characterised living donors with pancreas biopsies
- Comparison
- Normal glucose tolerant vs Impaired glucose tolerant vs Type 2 diabetic
- Outcome
- In situ insulin synthesis, intra-islet ER stress and beta cell phenotype markers
Main finding
As reported in the abstract
- In situ altered insulin processing closely connected to in vivo worsening of beta cell function
- Activation of endoplasmic reticulum (ER) stress genes reflects alteration of insulin processing in situ
- Individual islets from NGT, IGT and T2D participants characterised with 17 markers; disease progression reconstructed
Original publication
Intra-islet insulin synthesis defects are associated with endoplasmic reticulum stress and loss of beta cell identity in human diabetes. Diabetologia. Published 25 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →