Transcriptomic heterogeneity of non-beta islet cells is associated with type 2 diabetes development in mouse models
Authors' conclusion
Our study indicates that the transcriptional heterogeneity of non-beta cells has an impact on intra-islet crosstalk and participates in beta cell (dys)function.
Study context
- Population
- Islet cells of obese mouse strains differing in diabetes susceptibility; human islets from donors at different stages of T2D
- Comparison
- Diabetes-susceptible NZO vs diabetes-resistant OB obese mice
- Outcome
- Non-beta islet cell heterogeneity
Methodological detailssingle-cell transcriptomics, mouse models, human islet dataset
- Single-cell transcriptomics
- Mouse models
- Human islet dataset
Main finding
As reported in the abstract
Heterogeneous subpopulations of alpha cells, delta cells and macrophages; mapped to human diabetes GWAS genes
133
Predominant alpha cell cluster in NZO: cellular stress and lower mitochondrial capacity (DEGs)
97
Delta cells in NZO: higher Hhex and Sst expression but lower somatostatin secretion than OB (DEGs)
184
Original publication
Transcriptomic heterogeneity of non-beta islet cells is associated with type 2 diabetes development in mouse models. Diabetologia. Published 7 November 2024. doi:10.
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