Effect of Dapagliflozin on Cardiac Function and Metabolic and Hormonal Responses to Exercise
Authors' conclusion
During exercise, GH may be more important than catecholamines in driving the shift from glucose to fatty acid metabolism by SGLT2 inhibitors. The 4-week crossover design showed changes in cardiac function were rapid in onset and reversible.
Study context
- Population
- People with T2Dcrossover
- Participants
- 9 people
- Comparison
- Dapagliflozin 4 weeks vs placebo 4 weeks
Methodological detailsdouble-blind, placebo-controlled, 4-week washout period
- Double-blind
- Placebo-controlled
- 4-week washout period
Primary result
As reported in the abstract
Metabolic and hormonal response during exercise protocol (40% and 70% VO2max) · after 4 weeks of each treatment
- Trend for lower insulin with dapagliflozin (DAPA)
- Adrenalin, noradrenalin and glucagon not different
- DAPA vs Placebo: P < 0.0001
- DAPA vs Placebo: P < 0.05
- DAPA vs Placebo: P < 0.0005
- DAPA vs Placebo: P = 0.01
Further findings
Arterial stiffness
- Cardiac function (echocardiography) · 3 days after exercise protocol
- P = 0.03
- Cardiac function (echocardiography) · 3 days after exercise protocol · indexed left atrial volume reduced with DAPA
- P = 0.045
- Cardiac function (echocardiography) · 3 days after exercise protocol · right ventricular e" reduced with DAPA
- P = 0.042
- Cardiac function (echocardiography): mean peak diastolic mitral annular velocity (e') increased with DAPA
Arterial stiffness
- Not different between treatments
Original publication
Effect of Dapagliflozin on Cardiac Function and Metabolic and Hormonal Responses to Exercise. J Clin Endocrinol Metab. Published 24 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →