Association between lower extremity arterial calcification and coronary arterial calcification in a population at increased risk of cardiovascular disease
Authors' conclusion
Higher femoral and crural calcification scores were associated with higher CAC. Moreover, the presence of femoral intimal, femoral medial and crural intimal calcification patterns was associated with increased CAC. It appears that arterial calcification is a systemic process which occurs simultaneously in various arterial beds.
Study context
- Population
- Individuals at high cardiovascular disease (CVD) risk from the ARTEMIS cohort who underwent CT of femoral, crural and coronary arteries; 74% men, 62.6±10.9 years
- Participants
- 405 individuals
- Exposure
- Femoral and crural calcification score and pattern vs CAC tertile
- Outcome
- CAC within tertile 3 (high) vs tertile 1 (low)
Methodological detailsmultivariable-adjusted multinomial logistic regression, replication in independent T2D cohort (Early-HFpEF)
- Multivariable-adjusted multinomial logistic regression
- Replication in independent T2D cohort (Early-HFpEF)
Main finding
As reported in the abstract
Odds of CAC tertile 3 vs tertile 1
- Femoral calcification score, per 100-point increase: OR 95% CI 1.09 to 1.37, p<0.001
- 1.23
- Crural calcification score, per 100-point increase: OR 95% CI 1.11 to 1.47, p=0.001
- 1.28
- Femoral intimal pattern: OR 95% CI 4.23 to 27.62, p<0.001
- 10.81
- Femoral medial pattern: OR 95% CI 3.92 to 27.38, p<0.001
- 10.37
- Crural intimal pattern: OR 95% CI 2.73 to 16.43, p<0.001
- 6.70
Observational data: associations, not effects.
Further findings
Replication analysis (Early-HFpEF, T2D)
- The replication analysis yielded similar results
Original publication
Association between lower extremity arterial calcification and coronary arterial calcification in a population at increased risk of cardiovascular disease. BMJ Open Diabetes Res Care. Published 8 February 2024. doi:10.
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