IDegLira for the real‐world treatment of type 2 diabetes in Italy. Final results from the REX observational study
Authors' conclusion
Switching to IDegLira in a real-world clinical setting is a valid therapeutic option for patients with T2D with inadequate glycaemic control on basal or BB insulin regimen and/or need to simplify their insulin therapy, with specific reasons and therapeutic goals according to different T2D management trajectories.
Study context
- Population
- Patients with T2D switching to IDegLira from basal insulin ± glucose-lowering medication with or without bolus insulin, 28 Italian diabetes centres; mean age 67.2 years, diabetes duration 15.7 years
- Participants
- 358 patients
- Exposure
- Switch to IDegLira from basal-only vs basal-bolus insulin regimen
- Outcome
- Change in HbA1c from baseline
- Follow-up
- 6 months after IDegLira initiation
Methodological detailsnon-interventional, multicentre, single-cohort, 28 Italian diabetes centres, Follow-up ≈18 months
- Non-interventional
- Multicentre
- Single-cohort
- 28 Italian diabetes centres
- Follow-up ≈18 months
Main finding
As reported in the abstract
Change in HbA1c
- HbA1c significantly decreased from IDegLira start to all study time points in the overall population
Observational data: associations, not effects.
Further findings
%
| Outcome | Basal | BB |
|---|---|---|
| Change in HbA1c at end of observation | −1.19 | −0.60 |
Patients achieving HbA1c <7% · 18 months
- Increased from baseline 12.9% (n = 43) to 40.3% (n = 110) at 18 months
Fasting blood glucose and body weight
- Significantly decreased in both groups, more in the BB group
Treatment changes among completed patients
- Intensification of treatment (mainly in the basal group)
- 14.3%
- Simplification of treatment (mainly in the BB group)
- 48.6%
Original publication
IDegLira for the real‐world treatment of type 2 diabetes in Italy. Final results from the REX observational study. Diabetes Obes Metab. Published 8 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →