All-Cause Mortality and Cardiovascular and Microvascular Diseases in Latent Autoimmune Diabetes in Adults
Authors' conclusion
Despite having fewer metabolic risk factors than type 2 diabetes, LADA has equal to higher risks of death, CVD, and retinopathy. Poorer glycemic control, particularly in LADAhigh, highlights the need for improved LADA management.
Study context
- Population
- Swedish adults with newly diagnosed diabetes (latent autoimmune diabetes in adults (LADA), T2D, adult-onset T1D) and controls without diabetes, 2007–2019
- Participants
- 550 / 2,001 / 1,573 / 2,355
- Exposure
- LADA vs T2D, adult-onset T1D and controls without diabetes
- LADAn = 550
- Type 2 diabetesn = 2,001
- Adult-onset type 1 diabetesn = 1,573
- Controln = 2,355reference
- Outcome
- All-cause mortality
Methodological detailsregister linkage
- Register linkage
Main finding
As reported in the abstract
Each group vs controlHazard ratio (95% CI)
LADA
1.44(1.03–2.02)
Adult-onset type 1 diabetes
2.31(1.75–3.05)
Type 2 diabetes
1.31(1.03–1.67)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD incidenceLADAhighvs Control | 1.67 (1.04–2.69) | |
| CVD incidenceType 2 diabetesvs Control | 1.53 (1.17–2.00) | |
| Retinopathy incidenceLADAvs Type 2 diabetes | 2.25 (1.64–3.09) | |
| 0.20.5125Hazard ratio (log scale) |
- Retinopathy incidence: higher in both LADAhigh and LADAlow; unavailable in type 1 diabetes
CVD incidence
- CVD incidence not elevated in LADAlow or type 1 diabetes
Retinopathy incidence
- Nephropathy incidence not higher in LADA than type 2 diabetes
Clinical characteristics · baseline and throughout follow-up
- More favorable blood pressure and lipid profiles but higher HbA1c in LADA than T2D, especially in LADAhigh, which resembled T1D
Original publication
All-Cause Mortality and Cardiovascular and Microvascular Diseases in Latent Autoimmune Diabetes in Adults. Diabetes Care. Published 28 August 2023. doi:10.
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