Adolescent “Lean Polycystic Ovary Syndrome (PCOS)” Is Characterized by Higher Insulin Resistance and Adverse Adipokine Profile
Authors' conclusion
Within this population-based cohort, adolescents with PCOS and BMI <85th percentile had greater insulin resistance and adipose tissue dysfunction vs without PCOS. PCOS-associated metabolic dysfunction exist even among adolescents with BMI <85th percentile.
Study context
- Population
- Female adolescents in the Project Viva prebirth cohort, mid-teen visit (mean age 17.7 years)females with mid-teen data
- Participants
- 358 adolescents
- Exposure
- PCOS vs without PCOS, within body mass index (BMI) <85th and ≥85th percentile
- PCOSn = 51
- Outcome
- Growth, adiposity and cardiometabolic biomarkers in BMI <85th percentile (PCOS n = 27)
- Follow-up
- Mid-teen visit
Methodological detailspopulation-based, longitudinal prebirth cohort, stratified by BMI category, unadjusted linear regression
- Population-based
- Longitudinal prebirth cohort
- Stratified by BMI category
- Unadjusted linear regression
Main finding
As reported in the abstract
β
−.57 years
95% CI −0.96 to −0.18
age at peak height velocity; earlier with PCOS
β
.77
95% CI 0.23–1.30
HOMA-IR; higher with PCOS
β
−.35
95% CI −0.65 to −0.06
adiponectin-leptin ratio; lower with PCOS
Observational data: associations, not effects.
Further findings
Biomarkers in BMI ≥85th percentile · mid-teen visit
- Similar biomarkers by PCOS status
Original publication
Adolescent “Lean PCOS” Is Characterized by Higher Insulin Resistance and Adverse Adipokine Profile. J Clin Endocrinol Metab. Published 8 December 2025. doi:10.
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