Reproductive endocrinology

Disordered Eating Behaviors During Adolescence and Risk of Polycystic Ovary Syndrome: A Prospective Cohort Study

J Clin Endocrinol MetabPublished Prospective cohort study

Authors' conclusion

Girls who binge eat during adolescence may have increased odds of developing PCOS.

Study context

Population
Female participants of the Growing Up Today Study, United States, 1996–2021; disordered eating self-reported on repeated questionnaires
Participants
6,208 participants
Exposure
Disordered eating behaviors in adolescence vs never
Outcome
Physician-diagnosed PCOS (adulthood), aOR by past-year frequency of binge eating, laxative use and self-induced vomiting
Methodological detailslongitudinal, multivariable logistic regression with generalized estimating equations
  • Longitudinal
  • Multivariable logistic regression with generalized estimating equations

Main finding

As reported in the abstract

PCOS
Each group vs never binge ateAdjusted odds ratio (95% CI)
Binge eating more than monthlycumulative
1.59(1.09–2.33)
Laxative use less than monthlycumulative; lower odds of PCOS
0.45(0.29–0.72)
Laxative use at least monthly
1.67(0.89–3.14)
Polycystic ovary syndrome (PCOS) cases identified
410 (7%)

Observational data: associations, not effects.

Further findings

Prevalence of disordered eating behaviors at least once during follow-up

Binge eating
2331 (38%)
Self-induced vomiting
1103 (18%)
Laxative use for weight control
701 (11%)

Original publication

Disordered Eating Behaviors During Adolescence and Risk of Polycystic Ovary Syndrome: A Prospective Cohort Study. J Clin Endocrinol Metab. Published 2 December 2025. doi:10.1210/clinem/dgaf609

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