Gestational diabetes & diabetes in pregnancy
Adipose tissue‐derived FABP4 mediates glucagon‐stimulated hepatic glucose production in gestational diabetes
Authors' conclusion
This study provides new insights into the role of adipose tissue-derived FABP4 in GDM, highlighting this adipokine, as a potential co-activator of glucagon-stimulated hepatic glucose production during pregnancy.
Study context
- Population
- Pregnant women at term with gestational diabetes mellitus (GDM) or normoglycaemia; biopsies of placenta, subcutaneous (sWAT) and visceral (vWAT) white adipose tissue
- Comparison
- GDM vs normoglycaemic pregnant women
- Outcome
- FABP4 expression and secretion; contribution to glucagon-stimulated hepatic glucose production
Main finding
As reported in the abstract
- FABP4 expressed in placenta, sWAT and vWAT of pregnant women at term
- Significantly increased FABP4 secretion from vWAT in GDM vs normoglycaemic pregnant women
- Neutralizing FABP4 from both normoglycaemic and GDM vWAT secretome decreased glucagon-stimulated hepatic glucose production
Original publication
Adipose tissue‐derived FABP4 mediates glucagon‐stimulated hepatic glucose production in gestational diabetes. Diabetes Obes Metab. Published 14 July 2023. doi:10.
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