Gestational diabetes & diabetes in pregnancy
Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus
Authors' conclusion
In addition to insulin resistance and upregulated insulin levels in normal pregnancy and GDM, aberrant PEDF levels can serve as a "fingerprint" of metabolic abnormalities during pregnancy. Thus, PEDF is a valuable biomarker but could interfere with the time course for early diagnosis and prognosis of GDM.
Study context
- Population
- Women with normal pregnancy and women with gestational diabetes mellitus (GDM)
- Outcome
- Plasma PEDF levels and GDM
Methodological detailslogistic regression, transgenic and knockout mouse models
- Logistic regression
- Transgenic and knockout mouse models
Main finding
As reported in the abstract
- Plasma pigment epithelium-derived factor (PEDF) levels increased in normal pregnancy and higher in GDM women
- Higher PEDF levels associated with increased risk of developing GDM
- PEDF a significant independent determinant of postpartum prediabetes in GDM women
- In vivo and in vitro, PEDF induced insulin resistance by inhibiting the insulin signaling pathway
Observational data: associations, not effects.
Original publication
Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus. J Clin Endocrinol Metab. Published 13 July 2023. doi:10.
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