Gestational diabetes & diabetes in pregnancy
Body Mass Index Trajectories in Children Exposed to Gestational Diabetes in Utero: A Nationwide Register-based Study
Authors' conclusion
Children exposed to GDM in utero differ widely in their BMI trajectory. The detection of risk profiles based on early BMI growth and infant and maternal characteristics provides an opportunity for future targeted care and prevention.
Study context
- Population
- Children exposed to gestational diabetes mellitus (GDM) in utero, born in Denmark January 2008–October 2019, Danish registries
- Participants
- 15,509 children
- Exposure
- Normal vs Late accelerating vs Early accelerating
- Outcome
- Distinct BMI trajectories from birth to 10 years of age and their associations with infant and maternal characteristics
- Follow-up
- Birth to 10 years
Methodological detailslatent class trajectory modeling, multiple linear regression
- Latent class trajectory modeling
- Multiple linear regression
Main finding
As reported in the abstract
BMI trajectory classes
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Characteristics of late accelerating trajectoryMore often born large for gestational age | P < 0.001 |
| Characteristics of early accelerating trajectoryEarly accelerating vs other groups | P < 0.001 |
- Characteristics of early accelerating trajectory: more boys, born small for gestational age, and mothers with higher pre-pregnancy body mass index (BMI)
Characteristics of late accelerating trajectory
- Children in late accelerating trajectory more often born large for gestational age
Characteristics of early accelerating trajectory
- Early accelerating trajectory: more boys, born small for gestational age, mothers with higher pre-pregnancy BMI vs other groups
Original publication
Body Mass Index Trajectories in Children Exposed to Gestational Diabetes in Utero: A Nationwide Register-based Study. J Clin Endocrinol Metab. Published 28 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →