Gestational diabetes & diabetes in pregnancy
Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus
Authors' conclusion
These findings suggest that GDM-obese pregnancy is specifically characterized by inadequate VAT remodeling and dysfunctional molecular signaling, which contribute to insulin resistance and hinder metabolic health.
Study context
- Population
- Nulliparous pregnant women, subgrouped as nonobese (BMI <30 kg/m²) or obese (BMI ≥30 kg/m²)
- Participants
- 56 women
- Exposure
- Gestational diabetes mellitus (GDM) vs normal glucose tolerant (NGT), subgrouped by obesity
- GDMn = 26
- NGTn = 30reference
- Outcome
- VAT, insulin signaling and metabolic markers
Main finding
As reported in the abstract
- Hyperinsulinemia and elevated homeostatic model assessment for insulin resistance (HOMA-IR) in GDM vs NGT
- Significant visceral adipose tissue (VAT) adipocyte hypoplasia in GDM-obese vs NGT-nonobese
- Significantly lower IRS-2 expression and elevated ser312 phosphorylation of IRS-1 in GDM-obese VAT vs NGT-nonobese
- Significantly elevated circulating leptin and placental adipsin secretion in GDM-obese
- Elevated circulating adipsin with reduced placental adiponectin secretion in GDM-nonobese
Observational data: associations, not effects.
Original publication
Defective Visceral Adipose Tissue Adaptation in Gestational Diabetes Mellitus. J Clin Endocrinol Metab. Published 30 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →