Gestational diabetes & diabetes in pregnancy
Increased Circulating IL-32 Is Associated With Placenta Macrophage-derived IL-32 and Gestational Diabetes Mellitus
Authors' conclusion
Increased circulating IL-32 throughout pregnancy was closely associated with placenta macrophage-derived IL-32 expression and GDM. First trimester IL-32 level in peripheral blood may serve to predict the development of GDM.
Study context
- Population
- Pregnant women with and without gestational diabetes mellitus (GDM); first-trimester C-reactive protein (CRP), placental tissue and circulating cytokines (IL-32, IL-6, TNF-α) assessed
- Participants
- 186 vs 186
- Comparison
- Women with GDM vs women without GDM
- GDMn = 186
- Without GDMn = 186reference
- Outcome
- Circulating and placenta-derived IL-32 and inflammatory markers
Main finding
As reported in the abstract
- Circulating IL-32 throughout pregnancy was increased in GDM and related to placental-derived IL-32 expression, circulating IL-6 and TNF-α, glucose and insulin resistance index
- Placenta-derived IL-32 expression was increased in GDM and located in placental macrophages
- First-trimester CRP was closely associated with glucose and insulin resistance index and independently correlated with development of GDM
- Placenta-derived CRP expression was dramatically elevated in GDM
- IL-6, TNF-α and p-p38 expression up-regulated in GDM placental tissue; IL-6 or TNF-α colocated with IL-32
Observational data: associations, not effects.
Original publication
Increased Circulating IL-32 Is Associated With Placenta Macrophage-derived IL-32 and Gestational Diabetes Mellitus. J Clin Endocrinol Metab. Published 14 September 2023. doi:10.
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