Accelerated Longitudinal Glycemic Changes in Relation to Urinary Toxic/Essential Metals and Metal Mixtures Among Mexican Americans Living in Starr County, Texas
Authors' conclusion
In this underrepresented, high-risk Mexican American population, exposure to toxic metals and alterations in essential metal homeostasis were associated with faster increases in glycemia over time that may accelerate type 2 diabetes development.
Study context
- Population
- Mexican American adults in Starr County, Texas, selected based on self-reported diabetes status, followed over 3 years
- Participants
- 510 adults
- Exposure
- Higher vs lower baseline urinary metal levels
- Outcome
- Per-month changes in HbA1c, FPG and postload glucose in relation to baseline urinary metal levels
- Follow-up
- Over 3 years
Methodological detailslongitudinal, linear mixed-effects models, metal mixture analyses
- Longitudinal
- Linear mixed-effects models
- Metal mixture analyses
Main finding
As reported in the abstract
Per-month changes in glycemic traits
- Higher urinary arsenic, selenium, copper, molybdenum, nickel and tin associated with faster increases in glycemia (adjusted)
- Toxic metal mixture (arsenic, lead, cadmium, nickel, tin) associated with faster increases in postload glucose
- After adjustment
Observational data: associations, not effects.
Further findings
Predicted acceleration of conversion from normoglycemia (postload glucose criteria), highest vs lowest arsenic
Months
- To prediabetes
- 23
- To diabetes
- 65
Original publication
Accelerated Longitudinal Glycemic Changes in Relation to Urinary Toxic/Essential Metals and Metal Mixtures Among Mexican Americans Living in Starr County, Texas. Diabetes Care. Published 15 September 2024. doi:10.
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