Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans
Authors' conclusion
We conclude OC-active is associated with SI, without mediation by adipokines or body fat. As there was no association with measures of β-cell compensation for insulin resistance, the association between OC-active and insulin secretion reflects the compensatory response to SI.
Study context
- Population
- Mexican Americans without T2D from 342 families, Los Angeles County (BetaGene study)342 families
- Participants
- 867 participants
- Outcome
- Association of OC (inactive and active forms) with T2D-related quantitative traits; mediation by adipokines
Methodological detailsfamily-based
- Family-based
Main finding
As reported in the abstract
Association of OC-active with T2D-related quantitative traits
- Osteocalcin (OC)-active negatively associated with insulin sensitivity (SI)
- P = 2.1 × 10-3
- OC-active positively associated with insulinogenic index
- P = 2.8 × 10-3
- Acute insulin response marginally significantly associated with OC-active
- P = .07
Observational data: associations, not effects.
Original publication
Effect of Osteocalcin on Insulin Sensitivity, Insulin Secretion, and β-cell Compensation in Mexican Americans. J Clin Endocrinol Metab. Published 11 August 2025. doi:10.
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