Effect of insulin sensitivity, insulin secretion, and beta cell function on the remission of type 2 diabetes: A post hoc analysis of the IDEATE trial
Authors' conclusion
These findings supported the importance of aggressively implementing intensive lifestyle interventions for individuals with type 2 diabetes at an early stage of the disease, when beta cell function was not yet significantly impaired, to promote achieving diabetes remission.
Study context
- Population
- Individuals with T2D with HbA1c data at baseline and after intervention
- Participants
- 301 individuals
- Comparison
- Diabetes remission vs non-remission; diet, exercise and lifestyle education interventions
- Primary endpoint
- Probability of achieving diabetes remission by phenotypes of insulin sensitivity, insulin secretion and beta cell function
Primary result
As reported in the abstract
- Higher baseline disposition index (DI) or adaptation index: more likely to achieve remission
- Remission had significantly greater increase in AUCc-pep0-30/AUCgluc0-30, DI and adaptation index vs non-remission
- No between-group differences in insulin sensitivity indexes
- Greater increases in insulin secretion and beta cell function: more likely to achieve remission
Further findings
- Beta cell function indexes improved in all intervention groups; diet induced significant improvement vs lifestyle education
Original publication
Effect of insulin sensitivity, insulin secretion, and beta cell function on the remission of type 2 diabetes: A post hoc analysis of the IDEATE trial. Diabetes Obes Metab. Published 13 January 2025. doi:10.
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