First-year oral antidiabetic adherence and long-term complications in newly diagnosed type 2 diabetes
Authors' conclusion
Early adherence to OADs was associated with a reduced risk of complications and mortality in T2D patients. Promoting adherence in newly diagnosed individuals is crucial for improving long-term outcomes.
Study context
- Population
- Patients newly diagnosed with T2D in 2009 who initiated OAD monotherapy within 12 months
- Participants
- 65,340 patients
- Exposure
- Good vs poor first-year OAD adherence
- Good adherencen = 30,657
- Outcome
- Macrovascular events, diabetes-related hospitalizations and all-cause mortality
Methodological detailsnationally representative health claims database, inverse probability of treatment weighting
- Nationally representative health claims database
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
Macrovascular events: lower risk with good vs poor adherence
23 %
Diabetes-related hospitalizations: lower risk with good vs poor adherence
8%
All-cause mortality: lower risk with good vs poor adherence
28 %
Observational data: associations, not effects.
Original publication
First-year oral antidiabetic adherence and long-term complications in newly diagnosed type 2 diabetes. Diabetes Res Clin Pract. Published 11 August 2025. doi:10.
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