The association of glycaemic risk factors and diabetes duration with risk of heart failure in people with type 2 diabetes: A systematic review and meta‐analysis
Authors' conclusion
Glycaemic risk factors and diabetes duration significantly contribute to the heightened risk of HF among individuals with T2D. A reduction in risk of HF is anticipated with better management of glycaemic risk factors.
Study context
- Population
- Individuals with T2D
- Participants
- 4,102,589 individuals40 studies
- Comparison
- Glycaemic risk factors and diabetes duration vs risk of heart failure (HF)
- Outcome
- Risk of HF
Methodological detailsrandom-effects model, modified Newcastle-Ottawa Scale risk of bias, Egger's test and trim-and-fill for publication bias, All included studies scored high in the risk of bias assessment
- Random-effects model
- Modified Newcastle-Ottawa Scale risk of bias
- Egger's test and trim-and-fill for publication bias
- All included studies scored high in the risk of bias assessment
Pooled result
As reported in the abstract
Increase in HF risk per percentage point increase in HbA1c (significant)
15%
Increase in HF risk per additional year of diabetes duration (significant)
2%
Increase in HF risk with history of severe hypoglycaemia (significant)
43%
Increase in HF risk per unit increase in HbA1c variability metrics (HbA1c SD, CV, average successive variability)
20%-26%
Further pooled results
- Egger's test suggested publication bias; trim-and-fill: significant increase in HF risk per percentage point increase in HbA1c
- 14%
Original publication
The association of glycaemic risk factors and diabetes duration with risk of heart failure in people with type 2 diabetes: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 13 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →