1-Hour Postload Glucose: Early Screening for High Risk of Type 2 Diabetes in Koreans With Normal Fasting Glucose
Authors' conclusion
Even with normal fasting plasma glucose, a 1-h PG ≥ 155 mg/dL indicates lower insulin sensitivity similar to IGT and increased T2DM risk, making it a more effective early screening tool than 2-h PG.
Study context
- Population
- Korean adults with normal fasting plasma glucose
- Participants
- 7,504 adults
- Exposure
- Normal glucose tolerance (NGT) with 1-h PG ≥155 mg/dL and impaired glucose tolerance (IGT) vs NGT with 1-h PG <155 mg/dL
- Outcome
- Incident T2D
- Follow-up
- Mean 7.4 years
Main finding
As reported in the abstract
Hazard ratio
5.47
IGT
Hazard ratio
2.74
NGT and 1-h PG ≥ 155 mg/dL
- T2D developed (overall)
- 960 patients (12.8%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Composite insulin sensitivity index at baselineNGT and 1-h PG ≥ 155 mg/dL vs IGT · similarly reduced | P = 0.076 |
Prediction of T2D (ROC analysis)
- AUC of 1-h PG, higher than other glycemic parameters incl. 2-h PG
- 0.772
Original publication
1-Hour Postload Glucose: Early Screening for High Risk of Type 2 Diabetes in Koreans With Normal Fasting Glucose. J Clin Endocrinol Metab. Published 14 September 2024. doi:10.
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