Abnormal Glucagon Secretion Contributes to a Longitudinal Decline in Glucose Tolerance
Authors' conclusion
These data show that α-cell dysfunction accompanies a decline in β-cell function as IGT or overt type 2 diabetes develops.
Study context
- Population
- Individuals without diabetes (age 55 ± 1 years; BMI 27.7 ± 0.4), academic medical center
- Participants
- 96 individuals
- Exposure
- Progressors vs nonprogressors in glucose tolerance
- Progressorsn = 32
- Outcome
- Glucose tolerance status (categorical), then symmetrical percentage change in peak and 120-minute OGTT glucose (continuous)
- Follow-up
- 3 years
Methodological detailssingle-centre clinical research unit, 2 occasions 3 years apart, oral 75-g glucose challenge
- Single-centre clinical research unit
- 2 occasions 3 years apart
- Oral 75-g glucose challenge
Main finding
As reported in the abstract
Progression from normal to IGT or IGT to T2D
Individuals who progressed
32
Observational data: associations, not effects.
Further findings
Disposition index (DI) in progressors, baseline vs 3 years (10-4 dL/kg/min per μU/mL)
- DI declined in progressors
- 568 ± 98 vs 403 ± 65; P = .04
α-Cell suppression by glucose (δGSR/δglucose), baseline vs 3 years (nmol/min/L)
- Nonprogressors: did not change
- 1.5 ± 0.1 vs 1.3 ± 0.1; P = .37
- Progressors: decreased
- 1.0 ± 0.2 vs 0.8 ± 0.2; P < .01
Original publication
Abnormal Glucagon Secretion Contributes to a Longitudinal Decline in Glucose Tolerance. J Clin Endocrinol Metab. Published 3 January 2025. doi:10.
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