Improved Glycemic Control in Insulin-Treated Individuals With Poorly Controlled Type 2 Diabetes Through Combined Structured Education With Real-Time Continuous Glucose Monitoring
Authors' conclusion
In adults with poorly controlled insulin-treated T2D, rt-CGM use with structured education significantly improved the HbA1c and CGM metrics, primarily by reducing hyperglycemia, regardless of age.
Study context
- Population
- Insulin-treated adults with poorly controlled T2D (HbA1c ≥7.8%); each cohort 15 participants aged ≥60 years64 included in results
- Participants
- 66 adults
- Comparison
- Structured individualized education plus real-time continuous glucose monitoring (rt-CGM) (Dexcom G6), MDI and basal insulin cohorts
- MDIn = 33
- Basal insulinn = 33
- Outcome
- Change in HbA1c from baseline
- Follow-up
- Week 16
Methodological detailsmulticenter, 16-week
- Multicenter
- 16-week
Main finding
As reported in the abstract
Change in mean HbA1c · baseline to 16 weeks
Difference, % (95% CI)
MDI9.0% at baseline to 7.1% at 16 weeks
−1.8(−2.3 to −1.3)
Basal insulin8.8% to 7.0%
−1.8(−2.1 to −1.4)
Further findings
TIR 70–180 mg/dL, total population
- Mean TIR increase
- 25.2% (6 hours 4 minutes; 95% CI 20.6 to 29.8)
Time in tight range 70–140 mg/dL, total population
- Increase
- 17.3% (4 hours 10 minutes; 95% CI 14.0 to 20.7)
Improvements by age (≥60 vs <60 years)
- Improvements in HbA1c and CGM metrics comparable between ages ≥60 and <60 years
- all P-values for interaction >.1
Safety
- Both groups maintained target of <1% of time below range <54 mg/dL
Original publication
Improved Glycemic Control in Insulin-Treated Individuals With Poorly Controlled Type 2 Diabetes Through Combined Structured Education With Real-Time Continuous Glucose Monitoring. J Diabetes Sci Technol. Published 3 January 2025. doi:10.
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