Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes
An erratum to this article was published (Cardiovasc Diabetol, 3 May 2025 ↗)
Authors' conclusion
This study demonstrated a positive association between VAT and LV-GLS. This relationship was consistently observed using the clinical surrogate METS-VF. Visceral adiposity was identified as a strong mediator in the relationship between IR and LV-GLS, underscoring its role in the pathophysiology of cardiovascular disease in patients with T2D.
Study context
- Population
- Adults living with T2D; median age 57 (IQR 49–64), 63% women
- Participants
- 195 adults
- Outcome
- Association of VAT (bioimpedance) with LV-GLS (speckle tracking echocardiography)
Methodological detailscausal mediation analysis, adjusted linear regression guided by directed acyclic diagrams
- Causal mediation analysis
- Adjusted linear regression guided by directed acyclic diagrams
Main finding
As reported in the abstract
Visceral adipose tissue (VAT) vs left ventricular global longitudinal strain (LV-GLS), adjusted β
0.482
95% CI 0.060–0.904p = 0.039
Proportion of total effect between insulin resistance (IR) and LV-GLS mediated by VAT
60.9%
95% CI 15.82–171
Observational data: associations, not effects.
Further findings
Association of Metabolic Score for Visceral Fat (METS-VF) (VAT surrogate) with LV-GLS
- Effect strongly replicated using METS-VF as a surrogate for VAT
Original publication
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