Weight change in patients with new‐onset type 2 diabetes mellitus and its association with remission: Comprehensive real‐world data
Main finding · Diabetes remission (FPG <126 mg/dl at ≥2 consecutive examinations after stopping medication)Result — go to the resultAOR for remission 2.56 95% CI 2.35–2.79Authors' conclusion
Weight loss within the first 2 years of treating type 2 diabetes mellitus was associated with diabetes remission. Physicians should pay more attention to weight management in new-onset type 2 diabetes mellitus, particularly for young and obese individuals.
Study context
- Population
- Korean adults with new-onset T2D diagnosed 2009–2012, followed to 2017, Korean National Health Insurance Service health examination database
- Exposure
- Weight loss >5% vs stable body weight
- Weight lossn = 23,156
- Outcome
- Diabetes remission: FPG <126 mg/dl at ≥2 consecutive health examinations after stopping medication
Methodological detailsnationwide health examination database, real-world data
- Nationwide health examination database
- Real-world data
Main finding
As reported in the abstract
Diabetes remission (FPG <126 mg/dl at ≥2 consecutive examinations after stopping medication)
AOR for remission
2.56
95% CI 2.35–2.79
Weight lossvs Stable body weight
aOR for remission 2.56 (95% CI 2.35–2.79)
- Achieved remission (all patients)
- 2429 (2.1%)
Observational data: associations, not effects.
Further findings
Sensitivity analysis by degree of weight change
- The greater the weight loss, the higher the likelihood of remission
Subgroups
- Effect of weight loss on remission significantly greater in age <65 years, male sex and BMI >25
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Weight change in patients with new‐onset type 2 diabetes mellitus and its association with remission: Comprehensive real‐world data. Diabetes Obes Metab. Published 8 November 2023. doi:10.
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