Triglycerides/HDL cholesterol ratio and type 2 diabetes incidence: Panasonic Cohort Study 10
Authors' conclusion
The ratio of TG/HDL-C was found to be a stronger predictor of T2D development within 10 years than LDL-C, HDL-C, or TG, indicating that it may be useful in future medical treatment support.
Study context
- Population
- Participants in the health examination database at Panasonic Corporation, 2008–2017
- Participants
- 120,613 participants
- Exposure
- Triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C) ratio vs LDL-C, HDL-C and TG alone for predicting T2D
- Outcome
- Incident T2D (FPG 126 mg/dL, self-reported history of diabetes, or antidiabetic medicines)
Methodological detailsoccupational health examination database, multivariable Cox regression, time-dependent ROC analysis
- Occupational health examination database
- Multivariable Cox regression
- Time-dependent ROC analysis
Main finding
As reported in the abstract
Incident T2D · median follow-up 6.0 (3-10) years
- Developed T2D
- 6,080
- TG/HDL-C ratio per unit, multivariable HR
- 1.03 (1.02-1.03) (95% CI)
- AUC of TG/HDL-C ratio for T2D after 10 years
- 0.679
- Cut-off of TG/HDL-C ratio for T2D after 10 years
- 2.1
- AUC of TG/HDL-C ratio considerably larger than that of LDL-C, HDL-C and TG alone
- all P < 0.001
Observational data: associations, not effects.
Further findings
Subgroup analysis by sex and BMI
- Interaction effect between sex, BMI and lipid profiles
- Females and participants with BMI < 25 kg/m² showed a higher correlation between lipid profile levels and T2D onset
Original publication
Triglycerides/HDL cholesterol ratio and type 2 diabetes incidence: Panasonic Cohort Study 10. Cardiovasc Diabetol. Published 8 November 2023. doi:10.
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