Triglycerides to high density lipoprotein cholesterol ratio (TG/HDL), but not triglycerides and glucose product (TyG) index, is associated with arterial stiffness in prediabetes
Authors' conclusion
In preD, TG/HDL was independently associated with PWV, suggesting its possible role as a simple, cost-effective tool for assessing CV risk.
Study context
- Population
- Individuals without diagnosis of diabetes undergoing complete biochemistry, OGTT, arterial stiffness (PWV, AugI) and intima-media-thickness (IMT) assessment
- Participants
- 377 individuals
- Exposure
- TG/HDL and TyG index vs arterial stiffness in prediabetes; Normal-glucose-tolerance (NGT) vs prediabetes (preD) vs ND-T2D
- NGTn = 100reference
- preDn = 216
- ND-T2Dn = 61
- Outcome
- Association of TG/HDL and TyG with cardiovascular (CV) risk assessed through arterial stiffness (PWV) in preD
Main finding
As reported in the abstract
Association of TG/HDL, TyG and HOMA-IR with PWV in preD, adjusted for major confounders
- PWV correlated with TG/HDL (β)
- 0.16; P = 0.03
- Trend of association of PWV with HOMA-IR (β)
- 0.19, P = 0.07
- Higher tertile of TG/HDL associated with higher PWV (logistic regression, OR 2.51, 95% CI 1.01-6.29)
- P = 0.048
Observational data: associations, not effects.
Further findings
TG/HDL and TyG by glycaemic group
- TG/HDL and TyG higher in preD than NGT; no difference in TG/HDL between preD and ND-T2D
PWV, AugI and IMT by glycaemic group
- PreD had higher PWV, AugI and IMT than NGT
Original publication
Triglycerides to high density lipoprotein cholesterol ratio (TG/HDL), but not triglycerides and glucose product (TyG) index, is associated with arterial stiffness in prediabetes. Diabetes Res Clin Pract. Published 17 April 2025. doi:10.
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