Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants
Authors' conclusion
This study provided genetic evidence to support a potential causal mechanism between gut microbiota and AF and suggested the mediation role of AF risk factors.
Study context
- Population
- Genome-wide association studies (GWAS) summary statistics of 207 gut microbial taxa (Dutch Microbiome Project) and two large meta-GWASs of atrial fibrillation (AF); validation in FinnGen and >430,000 UK Biobank participants207 gut microbial taxa
- Comparison
- Genetically predicted gut microbial taxa and AF risk
- Outcome
- Causal relationships between gut microbiota and AF
Methodological detailstwo large meta-GWASs of AF, validation in FinnGen and UK Biobank, mediation Mendelian randomization (MR) analyses
- Two large meta-GWASs of AF
- Validation in FinnGen and UK Biobank
- Mediation MR analyses
Performance
As reported in the abstract
AF
Species Eubacterium ramulus: OR (95% CI), P, false discovery rate (FDR) adjusted P
1.08 (1.04-1.12), P = 0.0001, FDR adjusted p-value = 0.023
Genus Holdemania: OR (95% CI), P, FDR adjusted P
1.15 (1.07-1.25), P = 0.0004, FDR adjusted p-value = 0.042
Further findings
Incident AF risk in UK Biobank
- Genus Holdemania was associated with incident AF risk in the UK Biobank
Proportion of mediation effect
- Species Eubacterium ramulus via coronary artery disease (CAD) (95% CI), P
- 8.05% (1.73% - 14.95%), P = 0.008
- Genus Holdemania on AF via body mass index (BMI) (95% CI), P
- 12.01% (5.17% - 19.39%), P = 0.0005
Original publication
Roles of gut microbiota in atrial fibrillation: insights from Mendelian randomization analysis and genetic data from over 430,000 cohort study participants. Cardiovasc Diabetol. Published 8 November 2023. doi:10.
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