Analyses of potential causal contributors to increased waist/hip ratio‐associated cardiometabolic disease: A combined and sex‐stratified Mendelian randomization study
Authors' conclusion
MR suggests WHR increases the risk of CMD independent of these mediators, with the exception of dyslipidaemia in males, which is largely driven by the monounsaturated fatty acid to total free fatty acid ratio.
Study context
- Population
- European ancestries; summary statistics from the largest genome-wide association studies
- Comparison
- Genetically predicted increased waist/hip ratio (WHR), with and without adjustment for postulated mediators
- Outcome
- Effect of increased WHR on cardiometabolic traits (sex-combined Mendelian randomization (MR))
Methodological detailssex-combined and sex-stratified, summary statistics from genome-wide association studies in European ancestries
- Sex-combined and sex-stratified
- Summary statistics from genome-wide association studies in European ancestries
Main finding
As reported in the abstract
- HDL-C, beta (SE 0.029; p = 2.87E-47)
- −0.416
- TG, beta (SE 0.029; p = 1.87E-50)
- 0.431
- T2D, OR (SE 0.09; p = 26E-23)
- 2.747
- Coronary artery disease, OR (SE 0.045; p = 6.96E-18)
- 1.478
- Alanine transaminase, beta (SE 0.004; p = 6.88E-67)
- 0.062
- Systolic blood pressure, beta (SE 0.022; p = 7.81E-10)
- 0.134
- Diastolic blood pressure, beta (SE 0.026; p = 5.38E-10)
- 0.162
Further findings
Adjustment for mediators (sex-combined and females)
- Adjustment for the mediators attenuated WHR's effects, but associations remained significant, with concordant results in females
Males: effect of WHR after adjustment for monounsaturated fatty acid to total free fatty acid ratio
- HDL-C, beta (SE 0.069; p = .09)
- −0.117
- TG, beta (SE 0.068; p = .459)
- 0.051
- WHR effect no longer significant
Original publication
Analyses of potential causal contributors to increased waist/hip ratio‐associated cardiometabolic disease: A combined and sex‐stratified Mendelian randomization study. Diabetes Obes Metab. Published 15 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →