Allometric body shape indices, type 2 diabetes and kidney function: A two‐sample Mendelian randomization study
Authors' conclusion
Genetically high HI was associated with decreased risk of albuminuria, mediated through decreased T2D risk in both sexes. Opposite associations applied to genetically high ABSI and WHI in women only.
Study context
- Population
- Participants of European ancestry; summary statistics from UK Biobank, CKDGen and DIAGRAM
- Comparison
- Genetically predicted body mass index (BMI)-independent allometric body shape indices (A Body Shape Index (ABSI), Waist-Hip Index (WHI), Hip Index (HI)) and kidney function
- Outcome
- UACR, eGFR and blood urea nitrogen per 1-SD increase in genetically predicted ABSI, WHI and HI
Methodological detailsinverse variance-weighted random-effects Mendelian randomization (MR), sensitivity MR analyses
- Inverse variance-weighted random-effects MR
- Sensitivity MR analyses
Main finding
As reported in the abstract
UACR (log) per 1-SD increase
- ABSI, women: β 0.039 (95% CI 0.016, 0.063) log [urinary albumin-to-creatinine ratio (UACR)], P = 0.001
- WHI, women: β 0.028 (0.012, 0.044) log [UACR], P = 6 x 10-4
- ABSI and WHI: higher UACR in women, but not in men
- HI, women: β −0.021 (−0.041, 0.000) log [UACR], P = 0.05
- HI, men: β −0.026 (−0.058, 0.005) log [UACR], P = 0.10
Further findings
UACR in individuals with diabetes
- Corresponding estimates in individuals with diabetes were substantially augmented
Risk of T2D
- Increased for genetically high ABSI and WHI in women only
- P < 6 x 10-19
- Decreased for genetically high HI in both sexes
- P < 9 x 10-3
Other associations (eGFR, blood urea nitrogen)
- No other associations were observed
Original publication
Allometric body shape indices, type 2 diabetes and kidney function: A two‐sample Mendelian randomization study. Diabetes Obes Metab. Published 15 March 2023. doi:10.
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