Moderate-intensity Combined Training Induces Lipidomic Changes in Individuals With Obesity and Type 2 Diabetes
An erratum to this article was published (J Clin Endocrinol Metab, 13 Aug 2024 ↗)
Authors' conclusion
Our study revealed that 16 weeks of moderate-intensity CT remodeled the lipid metabolism in OB, and T2D individuals, even without dietary intervention, establishing a link between exercise-modulated lipid markers and mechanisms that reduce IR and obesity-related comorbidities.
Study context
- Population
- Middle-aged individuals of both sexes with normal weight, obesity (OB) and T2D
- Comparison
- 16 weeks of moderate-intensity combined training vs control period
- Outcome
- Plasma and white adipose tissue lipidome after 16 weeks of combined training
- Follow-up
- 16 weeks
Methodological detailsuntargeted lipidomics (ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS)), Combined training: 8 to 10 resistance exercises, then 35 min aerobic training (45%-70% VO2max), 3 times/week for 16 weeks
- Untargeted lipidomics (UHPLC-MS)
- Combined training: 8 to 10 resistance exercises, then 35 min aerobic training (45%-70% VO2max), 3 times/week for 16 weeks
Main finding
As reported in the abstract
- Increased polyunsaturated fatty acids in glycerophospholipids and glycerolipids
- P < .05
Further findings
Body composition, fitness and insulin resistance · 16 weeks
- Increased fat-free mass, VO2max and strength
- P < 0.05
- Reduced fat mass, circumferences and insulin resistance
Original publication
Moderate-intensity Combined Training Induces Lipidomic Changes in Individuals With Obesity and Type 2 Diabetes. J Clin Endocrinol Metab. Published 15 March 2024. doi:10.
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