Visceral adipose tissue and risk of diabetic nephropathy: A Mendelian randomization study
Authors' conclusion
This study provided genetic evidence that higher VAT mass was causally associated with a higher risk of DN.
Study context
- Comparison
- Genetically predicted higher visceral adipose tissue (VAT) mass and risk of diabetic nephropathy (DN)
- Outcome
- Causal association between VAT and diabetic nephropathy (DN)
Methodological detailsrandom-effects inverse-variance weighted (IVW) as primary method, sensitivity analyses
- Random-effects IVW as primary method
- Sensitivity analyses
Main finding
As reported in the abstract
Risk of DN per genetically predicted higher VAT mass
IVW (primary): Beta 0.948, OR
2.581
95% CI 2.100–3.173p = 1.980e-19
Weighted median (WM): Beta 1.126, OR
3.082
95% CI 2.278–4.171p = 2.997e-13
MR-Egger: Beta 1.315, OR
3.724
95% CI 1.981–6.998p = 6.446e-05
Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO): Beta 0.914, OR
2.493
95% CI 2.292–2.695p = 3.121e-16
Further findings
- No pleiotropy detected
- P = 0.230
Original publication
Visceral adipose tissue and risk of diabetic nephropathy: A Mendelian randomization study. Diabetes Res Clin Pract. Published 15 February 2024. doi:10.
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