Stress hyperglycemia ratio as a prognostic indicator for long-term adverse outcomes in heart failure with preserved ejection fraction
Main finding · Composite eventsResult — go to the resultAdjusted hazard ratio 2.34 95% CI 1.49–3.67Authors' conclusion
Elevated SHR was independently associated with an increased risk for composite events of all-cause, cardiovascular mortality, and HF readmission than those with lower SHR. SHR is a valuable tool for predicting and stratifying long-term adverse risks among HFpEF patients.
Study context
- Population
- HF with preserved ejection fraction (HFpEF) patients enrolled between 2015 and 2023
- Participants
- 400 patients
- Exposure
- High stress hyperglycemia ratio (SHR) vs low SHR
- High SHRn = 124
- Low SHRn = 276reference
- Outcome
- Composite of:
- All-cause mortality
- Cardiovascular mortality
- Heart failure (HF) rehospitalization
- Follow-up
- Mean 41 months
Methodological detailsOptimal SHR cut-off 0.99 identified by ROC analysis
- Optimal SHR cut-off 0.99 identified by ROC analysis
Main finding
Composite events · 41-month follow-up
Adjusted hazard ratio
2.34
95% CI 1.49–3.67
P < 0.001
High SHRvs Low SHR
aHR 2.34 (95% CI 1.49–3.67); P < 0.001
As reported in the abstract
- Patients with composite events
- 190 (47.5%)
Observational data: associations, not effects.
Further findings
SHR in patients with vs without events
- SHR significantly elevated in patients with events
- P < 0.001
Prognosis by left ventricular EF (LVEF) and SHR
- Poorer prognosis with 50 < LVEF < 60 and SHR > 0.99 vs other groups
- log-rank p < 0.001
Incremental prognostic value
- Adding SHR to MAGGIC score model gave incremental improvement in predicting adverse events
Correlation with N-terminal pro-brain natriuretic peptide (NT-proBNP)
- SHR displayed a slight correlation with NT-proBNP
Original publication
Stress hyperglycemia ratio as a prognostic indicator for long-term adverse outcomes in heart failure with preserved ejection fraction. Cardiovasc Diabetol. Published 13 February 2024. doi:10.
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