Association of high-sensitivity C-reactive protein and diabetic nephropathy in patients with type 2 diabetes: a Mendelian randomization study
Authors' conclusion
The current study provided experimental evidence that hsCRP level was causally related to DN. These findings suggest that the elevated hsCRP may be a causal risk factor for DN in patients with type 2 diabetes.
Study context
- Population
- Participants with T2D from the Taiwan Biobank database
- Participants
- 2,332 participants
- Comparison
- Genetically predicted high-sensitivity C-reactive protein (hsCRP) and diabetic nephropathy (DN) risk
- Outcome
- Causal relationship of hsCRP with DN risk (MR analysis)
Methodological detailstwo-stage regression model, unweighted and weighted genetic risk scores (four validated C-reactive protein (CRP) loci)
- Two-stage regression model
- Unweighted and weighted genetic risk scores (four validated CRP loci)
Performance
As reported in the abstract
DN per 1-unit increase in log-transformed genetically predicted hsCRP
OR, unweighted GRS
1.80
95% CI 1.51 to 2.14
OR, weighted GRS
1.67
95% CI 1.40 to 1.98
Further findings
Observational association of hsCRP level with DN
- Adjusted OR (95% CI 1.01 to 1.32), after multivariate adjustment
- 1.15
Association of genetic risk scores (GRSs) with DN (Mendelian randomization (MR) assumption check)
- Unweighted GRS, adjusted OR
- 1.00 (95% CI 0.92 to 1.09)
- Weighted GRS, adjusted OR
- 1.00 (95% CI 0.72 to 1.39)
- GRSs significantly associated with hsCRP; association with DN absent
Original publication
Association of high-sensitivity C-reactive protein and diabetic nephropathy in patients with type 2 diabetes: a Mendelian randomization study. BMJ Open Diabetes Res Care. Published 24 February 2023. doi:10.
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