Variable Diagnoses in Cases Referred for Discordant Thyroid Function Tests: Focus on Lymphoproliferative Disorders
Authors' conclusion
In patients referred for discordant TFTs, RTHβ is the most prevalent thyroid disorder, but variable assay interferences represent the most frequent condition.
Study context
- Population
- Consecutive patients referred to the Department of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano, for suspected central hyperthyroidism (discordant thyroid function tests (TFTs)), January 2017–February 2025
- Participants
- 144 patients
- Outcome
- Frequency of underlying diagnoses of discordant TFTs
Methodological detailsconsecutive patients, single-centre
- Consecutive patients
- Single-centre
Main finding
As reported in the abstract
Underlying diagnoses of discordant TFTs mimicking central hyperthyroidism
- Genuine rare thyroid disorders
- 44%
- Resistance to thyroid hormone beta (RTHβ)
- 32%
- TSH-secreting adenomas
- 7%
- Other diagnosis
- 5%
- Assay interference
- 56%
Observational data: associations, not effects.
Further findings
Interfering clonal paraproteins among assay-interference cases
- Clonal paraproteins detected
- 6/81
- Multiple myeloma
- 1 patient
- Type 1 cryoglobulinemia due to indolent marginal zone B non-Hodgkin lymphoma
- 1 patient
- Monoclonal gammopathy of uncertain significance
- 4 cases
- IgM kappa/lambda paraprotein
- 5 cases
- IgG kappa or IgA kappa paraprotein
- 1 case
Original publication
Variable Diagnoses in Cases Referred for Discordant Thyroid Function Tests: Focus on Lymphoproliferative Disorders. Thyroid. Published 30 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →