Is Thyroid Dysfunction Associated with Unruptured Intracranial Aneurysms? A Population-Based, Nested Case–Control Study from Korea
Authors' conclusion
Hypothyroidism is associated with an increased risk of unruptured IAs, whereas hyperthyroidism is associated with a reduced risk. Overall, the findings suggest that thyroid hormones may play a protective role in the development of unruptured IAs.
Study context
- Population
- National Health Insurance Service-National Sample Cohort, Korea, 2002–2019matched 1:15
- Participants
- 5,335 vs 80,025
- Exposure
- Thyroid diseases vs none, in unruptured IA cases vs controls
- Unruptured IAn = 5,335
- Controlsn = 80,025reference
- Outcome
- Association between thyroid diseases and unruptured IA (adjusted OR)
Methodological detailspopulation-based, nationwide, matched by age and sex 1:15, multivariable conditional logistic regression
- Population-based
- Nationwide
- Matched by age and sex 1:15
- Multivariable conditional logistic regression
Main finding
As reported in the abstract
Unruptured IA by thyroid disease history
History of hypothyroidism, aOR
1.46
CI 1.26–1.69
History of hyperthyroidism, aOR
0.71
CI 0.54–0.93
Observational data: associations, not effects.
Further findings
Thyroid hormone use >5 years among patients with hypothyroidism
- Long-term thyroid hormone use >5 years, aOR for unruptured IA
- 0.69 (CI 0.48-0.99)
Unruptured IA by sex
- Associations of hypothyroidism and hyperthyroidism with IA statistically significant in females but not in males
Univariate analysis
- Tobacco smoking, antihypertensive use and hypothyroidism significantly associated with elevated risk of unruptured IA
Original publication
Is Thyroid Dysfunction Associated with Unruptured Intracranial Aneurysms? A Population-Based, Nested Case–Control Study from Korea. Thyroid. Published 15 November 2023. doi:10.
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